Physalis peruviana L. Pulp Prevents Liver Inflammation and Insulin Resistance in Skeletal Muscles of Diet-Induced Obese Mice

• Published in: Nutrients Vol. 12; no. 3; p. 700
• Main Authors: Fuente, Francisco Pino-de la, Nocetti, Diego, Sacristán, Camila, Ruiz, Paulina, Guerrero, Julia, Jorquera, Gonzalo, Uribe, Ernesto, Bucarey, José Luis, Espinosa, Alejandra, Puente, Luis
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.03.2020; MDPI
• Subjects: Adipocytes; Adipose Tissue - metabolism; Animals; Antioxidants; Biomarkers; Body Weight; cape gooseberry; Carbohydrates; Cytokines; Diet; Diet, High-Fat; Disease Models, Animal; Fruit - chemistry; Fruits; Glucose; Glucose Tolerance Test; Hepatitis, Animal - etiology; Hepatitis, Animal - metabolism; Hepatitis, Animal - pathology; Hepatitis, Animal - prevention & control; Hepatocytes; High fat diet; Homeostasis; Inflammation; Inflammation Mediators - metabolism; Insulin; Insulin - metabolism; Insulin Resistance; lipid droplets; Lipid Peroxidation - drug effects; Lipids; Liver; Male; Metabolism; Mice; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscles; Musculoskeletal system; Obesity; Obesity - complications; Obesity - etiology; Obesity - metabolism; Oxidation; Oxidative stress; Physalis - chemistry; Physalis peruviana; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polyphenols; Protective Agents - chemistry; Protective Agents - pharmacology; Proteins; Skeletal muscle; Chile; United States > US; lipid droplets; Cape gooseberry; insulin resistance
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12030700

A chronic high-fat diet (HFD) produces obesity, leading to pathological consequences in the liver and skeletal muscle. The fat in the liver leads to accumulation of a large number of intrahepatic lipid droplets (LD), which are susceptible to oxidation. Obesity also affects skeletal muscle, increasing LD and producing insulin signaling impairment. L. (PP) (Solanaceae) is rich in peruvioses and has high antioxidant activity. We assessed the ability of PP to enhance insulin-dependent glucose uptake in skeletal muscle and the capacity to prevent both inflammation and lipoperoxidation in the liver of diet-induced obese mice. Male C57BL/6J mice were divided into groups and fed for eight weeks: control diet (C; 10% fat, 20% protein, 70% carbohydrates); C + PP (300 mg/kg/day); HFD (60% fat, 20% protein, 20% carbohydrates); and HFD + PP. Results suggest that PP reduces the intracellular lipoperoxidation level and the size of LD in both isolated hepatocytes and skeletal muscle fibers. PP also promotes insulin-dependent skeletal muscle glucose uptake. In conclusion, daily consumption of 300 mg/kg of fresh pulp of PP could be a novel strategy to prevent the hepatic lipoperoxidation and insulin resistance induced by obesity.