Pharmacological and toxicological effects of Paronychia argentea in experimental calcium oxalate nephrolithiasis in rats

• Published in: Journal of ethnopharmacology Vol. 129; no. 1; pp. 38 - 45
• Main Authors: Bouanani, S., Henchiri, C., Migianu-Griffoni, E., Aouf, N., Lecouvey, M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 04.05.2010; Amsterdam; New York: Elsevier; Elsevier
• Subjects: alanine transaminase; Alanine Transaminase - blood; Algerian herbal medicine; alkaline phosphatase; Alkaline Phosphatase - blood; animal models; Animals; Aqueous and butanolic extracts; aspartate transaminase; Biological and medical sciences; blood chemistry; body weight; Calcium oxalate; Calcium Oxalate - metabolism; Caryophyllaceae; cations; Creatinine - blood; Disease Models, Animal; dosage; dose response; enzyme activity; General pharmacology; hepatoprotective effect; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney Calculi - prevention & control; Liver - drug effects; Liver - enzymology; Liver - pathology; Male; Medical sciences; medicinal plants; medicinal properties; Necrosis - prevention & control; Nephrolithiasis; Nephrolithiasis - chemically induced; Nephrolithiasis - drug therapy; Nephrolithiasis - pathology; oral administration; Organ Size - drug effects; Oxalates; Paronychia; Paronychia argentea; Pharmacognosy. Homeopathy. Health food; pharmacology; Pharmacology. Drug treatments; Phytotherapy; Plant Components, Aerial; plant extracts; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; protective effect; Rats; Rats, Wistar; renal calculi; tissue weight; urea; Urea - blood; uric acid; Algeria; Paronychia argentea; Calcium oxalate; Nephrolithiasis; Algerian herbal medicine; Aqueous and butanolic extracts; Kidney disease; Urinary system disease; Rat; Pharmacognosy; Rodentia; Extract; Caryophyllaceae; Urinary stone; Medicinal plant; Vertebrata; Mammalia; Renal lithiasis; Folk medicine; Dicotyledones; Animal; Angiospermae; Plant origin; Calcium Oxalate; Spermatophyta; CELLS; OXIDATIVE STRESS; HERNIARIA-HIRSUTA; STONE FORMATION; IN-VITRO; UROLITHIASIS; KIDNEY; URINARY RISK-FACTORS; MEDICINAL-PLANTS; EXTRACT
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2010.01.056

Renal protection and antiurolithiasic effects of aqueous and butanolic extracts of Paronychia argentea (PA), a traditional Algerian plant commonly known as Algerian tea, were evaluated. Renal protection and antiurolithiasic effects of two extracts of Paronychia argentea (PA), a traditional Algerian plant commonly known as Algerian tea, were evaluated. This study was carried out to determine whether the aqueous extract (APA) or the butanolic extract (BPA) of aerial parts could prevent or reduce calculi aggregation in experimental calcium oxalate (Ox) nephrolithiasis in Wistar rats. The two extracts (APA and BPA) were administrated orally and daily, during 28 days to nephrolithiasic treated rats at the dose of 250, 500 mg/kg b.w. and 10, 20 mg/kg b.w. respectively. Body weight, renal index, liver index, serum level of creatinine, uric acid, urea, K +, Ca 2+, Mg 2+, Na + and transaminase (alanine aminotransferase, ALT; aspartate aminotransferase, AST), phosphatase alkaline activity (PAL) were evaluated following the 28 days treatment in rats. In addition histopathological changes in kidney and liver were stained in hematoxylin eosin (HE). The effect of the extracts could be advantageous in preventing urinary stone retention by reducing renal necrosis and thus inhibit crystal retention. In contradiction with APA, the two doses of BPA attenuated elevation in the serum creatinine ( p < 0.01) and blood urea levels ( p < 0.01) (nephroprotective effect). However, the increase in ALT (27%) and PAL (31–51%) serum levels and in the relative liver weights ( p < 0.01) in the groups treated with doses of APA may indicate that this extract has not a hepatoprotective effect against oxalate toxicity. The presented data indicate that administration of the butanolic extract of aerial parts to rats with NaOx induced lithiasis, and reduced and prevented the growth of urinary stones in experimental calcium oxalate nephrolithiasis in Wistar rats.