Clone-specific MYD88 L265P and CXCR4 mutation status can provide clinical utility in suspected Waldenstrom macroglobulinemia/lymphoplasmacytic lymphoma
Highlights • Sorted B- and plasma cells are clonally unrelated in the majority of suspected LPL. • MYD88 L265P is found in both fractions for confirmed WM, but not for suspected LPL. • Specificity of MYD88 L265P is enhanced when detected in both B- and plasma cells. • Sensitivity for CXCR4 analysis...
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Published in | Leukemia research Vol. 51; pp. 41 - 48 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.12.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Sorted B- and plasma cells are clonally unrelated in the majority of suspected LPL. • MYD88 L265P is found in both fractions for confirmed WM, but not for suspected LPL. • Specificity of MYD88 L265P is enhanced when detected in both B- and plasma cells. • Sensitivity for CXCR4 analysis is increased by flow cytometric cell sorting. • Magnetic beads cannot replace flow cytometric cell sorting for molecular analysis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0145-2126 1873-5835 |
DOI: | 10.1016/j.leukres.2016.10.008 |