Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A varie...

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Bibliographic Details
Published inMolecular cell Vol. 29; no. 1; pp. 1 - 7
Main Authors Wu, Ligang, Belasco, Joel G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 18.01.2008
Subjects
Animals
Caenorhabditis elegans - genetics
Drosophila melanogaster - genetics
Eukaryotic Initiation Factors - physiology
Gene Expression Regulation - genetics
Humans
MicroRNAs - genetics
Models, Genetic
Protein Biosynthesis - genetics
RNA Caps - genetics
RNA Interference
RNA Processing, Post-Transcriptional
RNA Stability - genetics
RNA, Helminth - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Small Interfering - genetics
RNA-Induced Silencing Complex - genetics
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Summary:The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2007.12.010