Effects of route and coadministration of recombinant raccoon poxviruses on immune responses and protection against highly pathogenic avian influenza in mice

Highlights ► We examined the protection of RCN constructs against HPAI challenge. ► We determined the immunogenicity of separate and mixed administration of RCN vaccines. ► We evaluated the protection conferred by combined ID and IN vaccination.

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Bibliographic Details
Published inVaccine Vol. 30; no. 45; pp. 6402 - 6408
Main Authors Kingstad-Bakke, Brock, Brewoo, Joseph N, Mai, Le Quynh, Kawaoka, Yoshihiro, Osorio, Jorge E
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 05.10.2012
Elsevier Limited
Subjects
Administration, Intranasal
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigens
avian influenza
chickens
enterotoxins
Escherichia coli
Female
Hemagglutinin Glycoproteins, Influenza Virus - immunology
hemagglutinins
HPAI
immune response
Immunogenicity
Immunoglobulin G - blood
Infections
Influenza A virus
Influenza A Virus, H5N1 Subtype
Influenza Vaccines - immunology
Injections, Intradermal
Mice
Mice, Inbred A
Mucosal
Neuraminidase - immunology
neutralizing antibodies
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Poxviridae
Poxviridae - immunology
Procyon lotor
Public health
Raccoon poxvirus
Taxonomy
vaccination
Vaccination - methods
Vaccine
Vaccines
Viruses
HPAI
Vaccine
Mice
Raccoon poxvirus
Mucosal
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Summary:Highlights ► We examined the protection of RCN constructs against HPAI challenge. ► We determined the immunogenicity of separate and mixed administration of RCN vaccines. ► We evaluated the protection conferred by combined ID and IN vaccination.
Bibliography:http://dx.doi.org/10.1016/j.vaccine.2012.08.018
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.08.018