c-Reactive protein and the metabolic syndrome in older Chinese: Guangzhou Biobank Cohort Study

• Published in: Atherosclerosis Vol. 194; no. 2; pp. 483 - 489
• Main Authors: Lao, X.Q, Thomas, G. Neil, Jiang, C.Q, Zhang, W.S, Yin, P, Adab, Peymane, Lam, Tai Hing, Cheng, K.K
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.10.2007; Elsevier
• Subjects: Aged; Aged, 80 and over; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; c-Reactive protein; C-Reactive Protein - analysis; Cardiology. Vascular system; Cardiovascular; Cardiovascular system; China; Chinese; Cohort Studies; Cross-Sectional Studies; Female; Humans; Injuries of the limb. Injuries of the spine; Male; Medical sciences; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - ethnology; Middle Aged; Odds Ratio; Pharmacology. Drug treatments; Risk Factors; Traumas. Diseases due to physical agents; Vascular risk factors; Vasodilator agents. Cerebral vasodilators; c-Reactive protein; Chinese; Metabolic syndrome; Vascular risk factors; Endocrinopathy; Systolic pressure; Diastolic pressure; Lipids; Cardiovascular disease; Glucose; Medical check up; Weight gain; Socioeconomics; Vascular disease; Body mass index; Cholesterol HDL; Cohort study; Atherosclerosis; Arterial pressure; Blood pressure; C reactive protein; Nutritional status; Human; Obesity; Fasting; Diabetes mellitus; Nutrition disorder; Metabolic diseases; Cholesterol LDL; Triglyceride; Hip; Risk factor; Hemodynamics; Pressure measurement
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2006.08.061

Abstract Objective To examine the association between serum c-reactive protein (CRP) concentration and the metabolic syndrome (MS) using the International Diabetes Federation Metabolic Syndrome Guidelines (April, 2005) definition in an older Chinese population. Methods Three thousand and fourteen men and 7275 women aged 50–85 years were recruited and received a full medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein. Data describing socioeconomic and lifestyle factors was also collected. Results Vascular risk factors including waist circumference, weight gain and waist gain since the age of 18, body mass index, waist–hip-ratio, triglyceride, HDL-cholesterol, and systolic and diastolic blood pressures were positively associated with CRP in both men and women ( p from <0.001 to 0.016). Compared to those without MS components, adjusted odds ratios for having elevated CRP increased in those with the MS or its components compared those without MS or components (all p < 0.001), except for the low HDL-cholesterol in both genders and raised fasting glucose in men. Similarly, the risk of elevated CRP increased with escalating MS components even after adjustment of a range of potential confounders. Conclusions There is a strong relationship between CRP and the constellation of MS components and associated vascular risk in this older Chinese population.