Serial cytokine levels in patients with severe sepsis

Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6,...

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Published inInflammation research Vol. 58; no. 7; pp. 385 - 393
Main Authors Wu, Huang-Pin, Chen, Chian-Kuang, Chung, Kong, Tseng, Jo-Chi, Hua, Chung-Ching, Liu, Yu-Chih, Chuang, Duen-Yau, Yang, Chung-Han
Format Journal Article
LanguageEnglish
Published Basel SP Birkhäuser Verlag Basel 01.07.2009
Springer Nature B.V
Subjects
Aged
Allergology
Biomedical and Life Sciences
Biomedicine
Cytokines - blood
Dermatology
Female
Humans
Immunology
Male
Neurology
Original Research Paper
Pharmacology/Toxicology
Rheumatology
Sepsis - blood
Sepsis - mortality
Human
Sepsis
Interleukin-10
Cytokine
Interleukin-6
Transforming growth factor-beta1
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Abstract Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-β1 from day 1 to day 7 were determined. Results IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. Conclusion IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
AbstractList The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear.OBJECTIVE AND DESIGNThe serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear.Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta1 from day 1 to day 7 were determined.METHODSSeventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta1 from day 1 to day 7 were determined.IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality.RESULTSIL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality.IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.CONCLUSIONIL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-β1 from day 1 to day 7 were determined. Results IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. Conclusion IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
Objective and design: The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods: Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-g, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-b1 from day 1 to day 7 were determined. Results: IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. Conclusion: IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-β1 from day 1 to day 7 were determined. IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta1 from day 1 to day 7 were determined. IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
Author Wu, Huang-Pin
Chen, Chian-Kuang
Liu, Yu-Chih
Hua, Chung-Ching
Chuang, Duen-Yau
Yang, Chung-Han
Chung, Kong
Tseng, Jo-Chi
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  givenname: Huang-Pin
  surname: Wu
  fullname: Wu, Huang-Pin
  email: whanpyng@cgmh.org.tw
  organization: Division of Pulmonary Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
– sequence: 2
  givenname: Chian-Kuang
  surname: Chen
  fullname: Chen, Chian-Kuang
  organization: Chang Gung University College of Medicine, Department of Emergence, Chang Gung Memorial Hospital
– sequence: 3
  givenname: Kong
  surname: Chung
  fullname: Chung, Kong
  organization: Chang Gung University College of Medicine, Department of Emergence, Chang Gung Memorial Hospital
– sequence: 4
  givenname: Jo-Chi
  surname: Tseng
  fullname: Tseng, Jo-Chi
  organization: Division of Pulmonary Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
– sequence: 5
  givenname: Chung-Ching
  surname: Hua
  fullname: Hua, Chung-Ching
  organization: Division of Pulmonary Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
– sequence: 6
  givenname: Yu-Chih
  surname: Liu
  fullname: Liu, Yu-Chih
  organization: Division of Pulmonary Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
– sequence: 7
  givenname: Duen-Yau
  surname: Chuang
  fullname: Chuang, Duen-Yau
  organization: Department of Chemistry, National Chung-Hsing University
– sequence: 8
  givenname: Chung-Han
  surname: Yang
  fullname: Yang, Chung-Han
  organization: Chang Gung University College of Medicine, Division of Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19262987$$D View this record in MEDLINE/PubMed
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Keywords Human
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Cytokine
Interleukin-6
Transforming growth factor-beta1
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Springer Nature B.V
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Snippet Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are...
The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear....
The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still...
Objective and design: The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are...
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SubjectTerms Aged
Allergology
Biomedical and Life Sciences
Biomedicine
Cytokines - blood
Dermatology
Female
Humans
Immunology
Male
Neurology
Original Research Paper
Pharmacology/Toxicology
Rheumatology
Sepsis - blood
Sepsis - mortality
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Title Serial cytokine levels in patients with severe sepsis
URI https://link.springer.com/article/10.1007/s00011-009-0003-0
https://www.ncbi.nlm.nih.gov/pubmed/19262987
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