Serial cytokine levels in patients with severe sepsis

Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6,...

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Published inInflammation research Vol. 58; no. 7; pp. 385 - 393
Main Authors Wu, Huang-Pin, Chen, Chian-Kuang, Chung, Kong, Tseng, Jo-Chi, Hua, Chung-Ching, Liu, Yu-Chih, Chuang, Duen-Yau, Yang, Chung-Han
Format Journal Article
LanguageEnglish
Published Basel SP Birkhäuser Verlag Basel 01.07.2009
Springer Nature B.V
Subjects
Aged
Allergology
Biomedical and Life Sciences
Biomedicine
Cytokines - blood
Dermatology
Female
Humans
Immunology
Male
Neurology
Original Research Paper
Pharmacology/Toxicology
Rheumatology
Sepsis - blood
Sepsis - mortality
Human
Sepsis
Interleukin-10
Cytokine
Interleukin-6
Transforming growth factor-beta1
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Summary:Objective and design The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Methods Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-γ, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-β1 from day 1 to day 7 were determined. Results IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. Conclusion IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
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ISSN:1023-3830
1420-908X
1420-908X
DOI:10.1007/s00011-009-0003-0