Experimental models of pancreatic cancer desmoplasia

• Published in: Laboratory investigation Vol. 98; no. 1; pp. 27 - 40
• Main Authors: Suklabaidya, Sujit, Dash, Pujarini, Das, Biswajit, Suresh, Voddu, Sasmal, Prakash K, Senapati, Shantibhusan
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.2018; Nature Publishing Group US; Nature Publishing Group
• Subjects: 13/106; 631/61/32; 631/67/1504/1713; 64/110; 64/60; Animal models; Animals; Animals, Genetically Modified; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biomedical Research - methods; Biomedical Research - trends; Cancer; Cell culture; Cell Line, Tumor; Disease Models, Animal; Drugs, Investigational - pharmacology; Drugs, Investigational - therapeutic use; Female; Fibroma - drug therapy; Fibroma - etiology; Fibroma - immunology; Fibroma - pathology; Fibrosis; Genetic engineering; Humans; In vitro methods and tests; In vivo methods and tests; Inflammation; Laboratory Medicine; Male; Medicine; Medicine & Public Health; Mice; mini-review; Neoplasm Transplantation - methods; Neoplasm Transplantation - trends; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - physiopathology; Pancreatic Stellate Cells - drug effects; Pancreatic Stellate Cells - immunology; Pancreatic Stellate Cells - pathology; Pancreatic Stellate Cells - transplantation; Pathogenesis; Pathology; Rats; Stellate cells; Tumor Cells, Cultured; Xenograft Model Antitumor Assays - methods

Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate c...