Experimental models of pancreatic cancer desmoplasia

• Published in: Laboratory investigation Vol. 98; no. 1; pp. 27 - 40
• Main Authors: Suklabaidya, Sujit, Dash, Pujarini, Das, Biswajit, Suresh, Voddu, Sasmal, Prakash K, Senapati, Shantibhusan
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.2018; Nature Publishing Group US; Nature Publishing Group
• Subjects: 13/106; 631/61/32; 631/67/1504/1713; 64/110; 64/60; Animal models; Animals; Animals, Genetically Modified; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Biomedical Research - methods; Biomedical Research - trends; Cancer; Cell culture; Cell Line, Tumor; Disease Models, Animal; Drugs, Investigational - pharmacology; Drugs, Investigational - therapeutic use; Female; Fibroma - drug therapy; Fibroma - etiology; Fibroma - immunology; Fibroma - pathology; Fibrosis; Genetic engineering; Humans; In vitro methods and tests; In vivo methods and tests; Inflammation; Laboratory Medicine; Male; Medicine; Medicine & Public Health; Mice; mini-review; Neoplasm Transplantation - methods; Neoplasm Transplantation - trends; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - physiopathology; Pancreatic Stellate Cells - drug effects; Pancreatic Stellate Cells - immunology; Pancreatic Stellate Cells - pathology; Pancreatic Stellate Cells - transplantation; Pathogenesis; Pathology; Rats; Stellate cells; Tumor Cells, Cultured; Xenograft Model Antitumor Assays - methods
• ISSN: 0023-6837; 1530-0307; 1530-0307
• DOI: 10.1038/labinvest.2017.127

Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.