Experimental models of pancreatic cancer desmoplasia

Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate c...

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Published inLaboratory investigation Vol. 98; no. 1; pp. 27 - 40
Main Authors Suklabaidya, Sujit, Dash, Pujarini, Das, Biswajit, Suresh, Voddu, Sasmal, Prakash K, Senapati, Shantibhusan
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 01.01.2018
Nature Publishing Group US
Nature Publishing Group
Subjects
13/106
631/61/32
631/67/1504/1713
64/110
64/60
Animal models
Animals
Animals, Genetically Modified
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biomedical Research - methods
Biomedical Research - trends
Cancer
Cell culture
Cell Line, Tumor
Disease Models, Animal
Drugs, Investigational - pharmacology
Drugs, Investigational - therapeutic use
Female
Fibroma - drug therapy
Fibroma - etiology
Fibroma - immunology
Fibroma - pathology
Fibrosis
Genetic engineering
Humans
In vitro methods and tests
In vivo methods and tests
Inflammation
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Mice
mini-review
Neoplasm Transplantation - methods
Neoplasm Transplantation - trends
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - immunology
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - physiopathology
Pancreatic Stellate Cells - drug effects
Pancreatic Stellate Cells - immunology
Pancreatic Stellate Cells - pathology
Pancreatic Stellate Cells - transplantation
Pathogenesis
Pathology
Rats
Stellate cells
Tumor Cells, Cultured
Xenograft Model Antitumor Assays - methods
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Abstract Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.
AbstractList Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.
Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.
Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, characterization, and use of pancreatic stellate cells in models of cancer-associated fibrosis. In addition to cell culture models, genetically engineered animal models have been established that spontaneously develop pancreatic cancer with desmoplasia. These animal models are currently being used for the study of pancreatic cancer pathogenesis and for evaluating therapeutics against pancreatic cancer. Here, we review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer.
Author Suklabaidya, Sujit
Sasmal, Prakash K
Dash, Pujarini
Das, Biswajit
Suresh, Voddu
Senapati, Shantibhusan
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  fullname: Senapati, Shantibhusan
  email: drsantibhusan@yahoo.com
  organization: Department of Translational Research, Tumor Microenvironment and Animal Models Lab, Institute of Life Sciences, Bhubaneswar, Odisha, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29155423$$D View this record in MEDLINE/PubMed
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Snippet Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the...
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SubjectTerms 13/106
631/61/32
631/67/1504/1713
64/110
64/60
Animal models
Animals
Animals, Genetically Modified
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biomedical Research - methods
Biomedical Research - trends
Cancer
Cell culture
Cell Line, Tumor
Disease Models, Animal
Drugs, Investigational - pharmacology
Drugs, Investigational - therapeutic use
Female
Fibroma - drug therapy
Fibroma - etiology
Fibroma - immunology
Fibroma - pathology
Fibrosis
Genetic engineering
Humans
In vitro methods and tests
In vivo methods and tests
Inflammation
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Mice
mini-review
Neoplasm Transplantation - methods
Neoplasm Transplantation - trends
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - immunology
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - physiopathology
Pancreatic Stellate Cells - drug effects
Pancreatic Stellate Cells - immunology
Pancreatic Stellate Cells - pathology
Pancreatic Stellate Cells - transplantation
Pathogenesis
Pathology
Rats
Stellate cells
Tumor Cells, Cultured
Xenograft Model Antitumor Assays - methods
Title Experimental models of pancreatic cancer desmoplasia
URI https://dx.doi.org/10.1038/labinvest.2017.127
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https://www.ncbi.nlm.nih.gov/pubmed/29155423
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