The Dominant Role of CD8⁺ Dendritic Cells in Cross-Presentation Is Not Dictated by Antigen Capture

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 103; no. 28; pp. 10729 - 10734
• Main Authors: Schnorrer, Petra, Behrens, Georg M. N., Wilson, Nicholas S., Pooley, Joanne L., Smith, Christopher M., El-Sukkari, Dima, Davey, Gayle, Kupresanin, Fiona, Li, Ming, Maraskovsky, Eugene, Belz, Gabrielle T., Carbone, Francis R., Shortman, Ken, Heath, William R., Villadangos, Jose A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.07.2006; National Acad Sciences
• Subjects: Animals; Antigens; Antigens - metabolism; Antigens, Bacterial - immunology; Antigens, Bacterial - metabolism; Biological Sciences; CD8 Antigens - biosynthesis; Cells, Cultured; Cross priming; Cross-Priming - immunology; Cytometry; Dendritic Cells - immunology; Dendritic Cells - metabolism; Latex; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Microspheres; Molecules; Ova; Ovalbumin - immunology; Ovalbumin - metabolism; Spleen; Spleen - cytology; Spleen - immunology; Spleen - metabolism; Spleen cells; Splenocytes; T lymphocytes; Vaccination

Mouse spleens contain three populations of conventional ($CD11c^{high}$) dendritic cells (DCs) that play distinct functions. The CD8⁺ DC are unique in that they can present exogenous antigens on their MHC class I molecules, a process known as cross-presentation. It is unclear whether this special ab...