Responses to booster hepatitis B vaccination are significantly correlated with genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated adolescents

• Published in: Human genetics Vol. 132; no. 10; pp. 1131 - 1139
• Main Authors: Wu, Tzu-Wei, Chu, Chen-Chung, Ho, Tzu-Ying, Chang Liao, Huei-Wen, Lin, Sheng-Kai, Lin, Marie, Lin, Hans Hsienhong, Wang, Li-Yu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013; Springer; Springer Nature B.V
• Subjects: Adolescence; Adolescent; Antibodies; Antigens; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Chromosomes; Drug dosages; Female; Gene Frequency; Gene Function; Genetic aspects; Genetic Loci; Genomes; Genomics; Genotype; Health aspects; Hepatitis B; Hepatitis B - prevention & control; Hepatitis B Antibodies - immunology; Hepatitis B vaccine; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; Hepatitis B virus; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DP beta-Chains - genetics; HLA-DP beta-Chains - metabolism; Human Genetics; Humans; Immunization; Immunization, Secondary; Infection; Infections; Leukocytes; Male; Medicine; Metabolic Diseases; Molecular Medicine; Odds Ratio; Original Investigation; Risk Factors; Teenagers; Vaccination; Vaccines; Youth; Taiwan; DBP1; Human Leukocyte Antigen; Abbott Diagnostics; Protective Allele; Booster Vaccination
• ISSN: 0340-6717; 1432-1203
• DOI: 10.1007/s00439-013-1320-5

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the human leukocyte antigen (HLA)- DP loci that were significantly correlated with outcomes of hepatitis B virus (HBV) infection. We performed a case–control study nested in a well-characterized cohort of booster recipients to assess whether genetic variants of HLA - DPB1 are also associated with response to hepatitis B (HB) vaccination. The cases and controls were 171 and 510 booster recipients whose post-booster titers of antibodies against HBV surface antigen (anti-HBs) were undetectable and detectable, respectively. The HLA - DPB1 genotype was determined using sequence-based techniques. The frequencies of HLA - DPB1 alleles were significantly different between cases and controls ( p  = 1.7 × 10 −8 ). The HLA - DPB1 05:01 and 09:01 alleles were significantly more frequent in the cases, and 02:01:02, 02:02, 03:01:01, 04:01:01 , and 14:01 , were significantly more frequent in the controls. The adjusted odds ratio (OR) of undetectable post-booster anti-HBs titers was significantly correlated with the number of risk alleles ( p for trend = 3.8 × 10 −5 ). For the number of protective alleles, the trend was significantly inversed ( p for trend = 1.3 × 10 −5 ). As compared with subjects with two risk alleles, adjusted OR were 0.34 (95 % confidence interval [CI] 0.21–0.55) and 0.20 (95 % CI 0.08–0.48) for subjects with 1 and 2 protective alleles, respectively. The HLA - DPB1 02:02 , 04:01:01 , 05:01 and 09:01 alleles were also significantly correlated with the likelihoods of undetectable pre-booster anti-HBs titers. Our results indicated that HLA - DPB1 is significantly correlated with response to booster HB vaccination in adolescent who had received postnatal active HB vaccination. HLA - DBP1 may also determine the long-term persistence of response to HB vaccination.