The Rundown of Dietary Supplements and Their Effects on Inflammatory Bowel Disease-A Review

• Published in: Nutrients Vol. 12; no. 5; p. 1423
• Main Authors: Malinowski, Bartosz, Wiciński, Michał, Sokołowska, Maya M, Hill, Nicholas A, Szambelan, Monika
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.05.2020; MDPI
• Subjects: abdominal cramping/pain; Antibiotics; Bacteria; Carbohydrates; Colitis, Ulcerative - therapy; Complications; Constipation; Crohn Disease - therapy; Crohn’s disease; Curcumin; Cytokines; Diarrhea; Diet; Diet - methods; Dietary Fiber - therapeutic use; Dietary Supplements; Disaccharides; Disease control; Drug therapy; E coli; Endoscopy; Fatty Acids - therapeutic use; Fibers; Gastrointestinal diseases; Health risks; Health services; Homeostasis; Humans; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - therapy; Intestine; Irritable bowel syndrome; Microbiota; Monosaccharides; Nutrient deficiency; Oligosaccharides; Pain; Pathogenesis; Patients; Pharmacology; Polyphenols; Polyphenols - therapeutic use; Probiotics; Probiotics - therapeutic use; Quality of Life; Remission; Resveratrol; Review; Risk assessment; Signs and symptoms; Treatment Outcome; Tumor necrosis factor-TNF; Ulcerative colitis; constipation; polyphenols; fibers; fatty acids; abdominal cramping/pain; low FODMAP; ulcerative colitis; diarrhea; inflammatory bowel disease; Crohn’s disease; probiotics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12051423

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are a life-long, chronic, and relapsing problem affecting 11.2 million people worldwide. To date, there is pharmacological therapy to treat symptoms such as diarrhea, constipation, and abdominal cramping/pain. These medications also help to alleviate everyday discomfort; however, there are no curative therapies. Recent studies have investigated the combination of pharmacological treatment along with nutritional interventions to improve quality of life and risk of disease relapse. Dietary supplements, specifically probiotics, polyphenols, fibers, fatty acids and low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diets (FODMAP diets), have been closely looked at to determine their effect, if any, on the development of inflammatory bowel disease and its course of progression. Approximately 30 studies were carefully reviewed and analyzed to appreciate the value of these above-mentioned supplements and their influence on this gastrointestinal disease. After analysis, it has been demonstrated that by implementing fibers, polyphenols, and fatty acids, as well as keeping a low-saccharide diet for those patients with Crohn's disease and ulcerative colitis can improve quality of life and invoke clinical remission. Some polyphenols, specifically curcumin and resveratrol, have proved to decrease disease activity in studies reviewed. Although these studies have become a topic of recent interest, it would be of great value to doctors and patients alike, to continue in this direction of research and to improve the findings for best treatment substances and dosages. This would lead to increased quality of life and disease control leading to fewer complications in the future.