Vitamin D and the Liver-Correlation or Cause?

Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses t...

Full description

Saved in:
Bibliographic Details
Published inNutrients Vol. 10; no. 4; p. 496
Main Authors Keane, Jeremy T, Elangovan, Harendran, Stokes, Rebecca A, Gunton, Jenny E
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.04.2018
MDPI
Subjects
Clinical trials
Disease
Homeostasis
Liver
Liver diseases
liver fibrosis
Medical research
Medical treatment
NAFLD
Review
VDR
Vitamin D
NAFLD
liver fibrosis
VDR
vitamin D
Online AccessGet full text

Cover

More Information
Summary:Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses the therapeutic potential of vitamin D-based treatments to protect against hepatic disease progression and to improve response to treatment. While pre-clinical experimental data is promising, clinical trials around liver diseases have mostly been under-powered, and further studies will be required to clarify whether vitamin D or vitamin D analogues have beneficial effects on liver disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10040496