Tricuspid valve flow measurement using a deep learning framework for automated valve‐tracking 2D phase contrast

• Published in: Magnetic resonance in medicine Vol. 92; no. 5; pp. 1838 - 1850
• Main Authors: Lamy, Jérôme, Gonzales, Ricardo A., Xiang, Jie, Seemann, Felicia, Huber, Steffen, Steele, Jeremy, Wieben, Oliver, Heiberg, Einar, Peters, Dana C.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2024
• Subjects: Adult; Algorithms; Aorta; Automation; Bias; Blood Flow Velocity; Correlation coefficients; Deep Learning; Diastole; Echocardiography; Engineering and Technology; Female; Flow measurement; Flow velocity; Humans; Image acquisition; Image contrast; Image Interpretation, Computer-Assisted - methods; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging, Cine - methods; Male; Measurement methods; Medical Engineering; Medical Image Processing; Medical Imaging; Medicinsk bildbehandling; Medicinsk bildvetenskap; Medicinteknik; Middle Aged; Phase contrast; Regurgitation; Reproducibility of Results; slice-following; Stroke Volume - physiology; Systole; Systole - physiology; Teknik; Tracking; Tricuspid valve; Tricuspid Valve - diagnostic imaging; Two dimensional flow; Velocity; Ventricle; deep learning; tricuspid valve; phase contrast; slice‐following; regurgitation
• ISSN: 0740-3194; 1522-2594; 1522-2594
• DOI: 10.1002/mrm.30163

Tricuspid valve flow velocities are challenging to measure with cardiovascular MR, as the rapidly moving valvular plane prohibits direct flow evaluation, but they are vitally important to diastolic function evaluation. We developed an automated valve-tracking 2D method for measuring flow through the dynamic tricuspid valve. Nine healthy subjects and 2 patients were imaged. The approach uses a previously trained deep learning network, TVnet, to automatically track the tricuspid valve plane from long-axis cine images. Subsequently, the tracking information is used to acquire 2D phase contrast (PC) with a dynamic (moving) acquisition plane that tracks the valve. Direct diastolic net flows evaluated from the dynamic PC sequence were compared with flows from 2D-PC scans acquired in a static slice localized at the end-systolic valve position, and also ventricular stroke volumes (SVs) using both planimetry and 2D PC of the great vessels. The mean tricuspid valve systolic excursion was 17.8 ± 2.5 mm. The 2D valve-tracking PC net diastolic flow showed excellent correlation with SV by right-ventricle planimetry (bias ± 1.96 SD = -0.2 ± 10.4 mL, intraclass correlation coefficient [ICC] = 0.92) and aortic PC (-1.0 ± 13.8 mL, ICC = 0.87). In comparison, static tricuspid valve 2D PC also showed a strong correlation but had greater bias (p = 0.01) versus the right-ventricle SV (10.6 ± 16.1 mL, ICC = 0.61). In most (8 of 9) healthy subjects, trace regurgitation was measured at begin-systole. In one patient, valve-tracking PC displayed a high-velocity jet (380 cm/s) with maximal velocity agreeing with echocardiography. Automated valve-tracking 2D PC is a feasible route toward evaluation of tricuspid regurgitant velocities, potentially solving a major clinical challenge.