The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

• Published in: Nutrients Vol. 12; no. 2; p. 590
• Main Authors: Yarparvar, Amirhossein, Elmadfa, Ibrahim, Djazayery, Abolghassem, Abdollahi, Zahra, Salehi, Forouzan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2020; MDPI
• Subjects: Adolescent; Adolescents; Autoimmune diseases; Bioassays; Biomarkers; Biomarkers - blood; Body mass; Body mass index; Body size; C-Reactive Protein - metabolism; Calciferol; Cardiovascular diseases; Chronic illnesses; Cytokines; Diet; Dietary intake; High density lipoprotein; Humans; Hypertension; Inflammation; Inflammation - blood; Interleukin 10; Interleukin 6; Levels; lipid profile; Lipids; Lipids - blood; Lipoproteins, HDL - blood; Lipoproteins, VLDL - blood; Male; Metabolic disorders; Metabolic syndrome; Serum levels; Serum lipids; Students; Teenagers; Tumor necrosis factor receptors; Tumor necrosis factor-TNF; Vitamin D; Vitamin D - blood; vitamin d status; Vitamin deficiency; Iran; China; Inflammation; Vitamin D status; Adolescent; lipid profile
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12020590

The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; = 36), 25 and above (ng/mL) (SVD ≥ 25; = 35), negative-hsCRP ( = 48), and positive-hsCRP ( = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.