Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

• Published in: Journal of clinical medicine Vol. 9; no. 5; p. 1417
• Main Authors: Sardu, Celestino, Gambardella, Jessica, Morelli, Marco Bruno, Wang, Xujun, Marfella, Raffaele, Santulli, Gaetano
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.05.2020; MDPI
• Subjects: Anticoagulants; Avian flu; Blood pressure; Clinical medicine; Coronaviruses; COVID-19; Diabetes; Disease; Endothelium; Gene expression; Glycoproteins; Hospitals; Hypertension; Infections; Morbidity; Mortality; Pathogenesis; Proteins; Review; Severe acute respiratory syndrome coronavirus 2; Thrombosis; Ventilators; COVID; heparin; blood pressure; catepsin; endothelium; Kawasaki disease; cytokine storm; coronavirus; ACE2, acute kidney injury

The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic diso...