Oxytocin does not modify GH, ACTH, cortisol and prolactin responses to Ghrelin in normal men

• Published in: Neuropeptides (Edinburgh) Vol. 45; no. 2; pp. 139 - 142
• Main Authors: Coiro, Vittorio, Volpi, Riccardo, Stella, Adriano, Cataldo, Simona, Chiodera, Paolo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2011; Elsevier
• Subjects: ACTH; Adrenocorticotropic Hormone - metabolism; Adult; Advanced Basic Science; Biological and medical sciences; Cortisol; Endocrinology & Metabolism; Fundamental and applied biological sciences. Psychology; Ghrelin; Ghrelin - administration & dosage; Ghrelin - metabolism; Human Growth Hormone - metabolism; Humans; Hydrocortisone - metabolism; Male; Oxytocin; Oxytocin - administration & dosage; Oxytocin - metabolism; PRL; Prolactin - metabolism; Vertebrates: endocrinology; Young Adult; ACTH; GH; Cortisol; PRL; Oxytocin; Ghrelin; Human; Corticosteroid; Steroid hormone; Hydrocortisone; Glucocorticoid; Adrenocorticotropic hormone; Adenohypophyseal hormone; Prolactin; Adrenal hormone
• ISSN: 0143-4179; 1532-2785
• DOI: 10.1016/j.npep.2010.12.007

Abstract Background In order to test the possible effect of Oxytocin (OT) on Ghrelin-stimulated GH, PRL, ACTH and cortisol, ten healthy normal men were studied. Methods Tests: Ghrelin (0.2 μg/kg body weight (BW)) as an iv bolus; Ghrelin plus OT (2 IU as bolus plus 0.07 IU/min administered for 90 min). Results The administration of OT did not change GH, PRL, ACTH and cortisol release induced by Ghrelin. Conclusions The data suggests that in humans OT did not modulate the GH, PRL, ACTH and cortisol response to Ghrelin.