A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria
A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria. S De Cosmo , A Argiolas , G Miscio , S Thomas , G P Piras , R Trevisan , P C Perin , S Bacci , L Zucaro , M Margaglione , L Frittitta , A Pizzuti , V Tassi , G C...
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Published in | Diabetes (New York, N.Y.) Vol. 49; no. 3; pp. 521 - 524 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Diabetes Association
01.03.2000
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Subjects | |
Online Access | Get full text |
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Summary: | A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes
and albuminuria.
S De Cosmo ,
A Argiolas ,
G Miscio ,
S Thomas ,
G P Piras ,
R Trevisan ,
P C Perin ,
S Bacci ,
L Zucaro ,
M Margaglione ,
L Frittitta ,
A Pizzuti ,
V Tassi ,
G C Viberti and
V Trischitta
Division and Research Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG),
Italy. endocrinologia@operapadrepio.it
Abstract
Insulin resistance characterizes type 1 diabetes in patients with albuminuria. A PC-1 glycoprotein amino acid variant, K121Q,
is associated with insulin resistance. We examined the impact of the PC-1 K121Q variant on the rate of decline of the glomerular
filtration rate (GFR) by creatinine clearance derived from the Cockroft-Gault formula in 77 type 1 diabetic patients with
albuminuria who were followed for an average of 6.5 years (range 2.5-15). Patients carrying the Q allele (n = 22; 20 with
KQ and 2 with QQ genotypes) had a faster GFR decline than those patients with the KK genotype (n = 55) (median 7.2 vs. 3.7
ml x min(-1) x year(-1); range 0.16 to 16.6 vs. -3.8 to 16.0 ml x min(-1) x year(-1); P < 0.001). Significantly more patients
carrying the Q allele belonged to the highest tertile of GFR decline (odds ratio = 5.7, 95% CI 4.1-7.2, P = 0.02). Levels
of blood pressure, HbA1c, and albuminuria were comparable in the two genotype groups. Albuminuria (P = 0.001), mean blood
pressure (P = 0.046), and PC-1 genotype (P = 0.036) independently correlated with GFR decline. Because all patients were receiving
antihypertensive treatment, the faster GFR decline in the patients carrying the Q allele could be the result of reduced sensitivity
to the renoprotective effect of antihypertensive therapy. PC-1 genotyping identifies type 1 diabetic patients with a faster
progression of diabetic nephropathy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0012-1797 1939-327X |
DOI: | 10.2337/diabetes.49.3.521 |