Design, Characterization, and Antimicrobial Evaluation of Copper Nanoparticles Utilizing Tamarixinin a Ellagitannin from Galls of Tamarix aphylla

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 2; p. 216
• Main Authors: Orabi, Mohamed A A, Salem-Bekhit, Mounir M, Taha, Ehab I, Abdel-Sattar, El-Shaymaa, Alqahtani, Omaish Salman, Al-Joufi, Fakhria A, Abdel-Wahab, Basel A, Alshabi, Ali Mohamed, Alyami, Hamad S, Ahmad, Javed, Hatano, Tsutomu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.02.2022; MDPI
• Subjects: antimicrobial activity; Antimicrobial agents; copper nanoparticles; ellagitannins; Green chemistry; green synthesis; Investigations; Morphology; Nanoparticles; Particle size; Scanning electron microscopy; tamarixinin A; Toxicity; copper nanoparticles; ellagitannins; antimicrobial activity; tamarixinin A; green synthesis
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph15020216

The application of plant extracts or plant-derived compounds in the green synthesis of metal nanoparticles (NPs) was researched. Determining the exact metabolite implicated in the formation of NPs would necessitate comprehensive investigations. Copper nanoparticles (CuNPs) are gaining a lot of attention because of their unique properties and effectiveness against a wide range of bacteria and fungi, as well as their potential for usage in catalytic, optical, electrical, and microelectronics applications. In the course of this study, we aimed to formulate CuNPs utilizing pure tamarixinin A (TA) ellagitannin isolated from galls. The main particle size of the formed CuNPs was 44 ± 1.7 nm with zeta potential equal to -23.7 mV, which emphasize the stability of the CuNPs. The X-ray diffraction spectroscopy showed a typical centered cubic crystalline structure phase of copper. Scanning electron microscopy images were found to be relatively spherical and homogeneous in shape. The antimicrobial properties of TA, as well as its mediated CuNPs, have been evaluated through well diffusion assays against four bacterial, NCTC 10400, ATCC 25923, ATCC 25922, and ATCC 27853, and two fungal, and , strains. The distinctive antimicrobial activities were noted against the fungal strains and the Gram-negative bacterial strains ATCC 27853, and ATCC 25922. In conclusion, CuNPs mediated by TA can be applied for combating a wide range of bacterial and fungal species especially , , and in a variety of fields.