nor-Lignans from the leaves of Styrax ferrugineus (Styracaceae) with antibacterial and antifungal activity

• Published in: Phytochemistry (Oxford) Vol. 55; no. 6; pp. 597 - 601
• Main Authors: Mendonça Pauletti, Patricia, Araújo, Angela Regina, Young, Maria Claudia Marx, Giesbrecht, Astréa M, da Silva Bolzani, Vanderlan
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.11.2000; Elsevier
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antibacterial activity; Antifungal activity; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; arylpropanoids; Biochemistry & Molecular Biology; Biological and medical sciences; Candida albicans - drug effects; Chemical constitution; Fundamental and applied biological sciences. Psychology; General pharmacology; Life Sciences & Biomedicine; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; lignin; Magnetic Resonance Spectroscopy; Magnoliopsida - chemistry; Medical sciences; Microbial Sensitivity Tests; Molecular Conformation; nor-Lignans; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plant physiology and development; Plant Sciences; Science & Technology; Staphylococcus aureus - drug effects; Styracaceae; Styrax ferrugineus; Asia; America; Antifungal activity; Antibacterial activity; Styrax ferrugineus; Styracaceae; nor-Lignans; antibacterial activity; PLANTS; antifungal activity; Molecular structure; Pharmacognosy; Plant leaf; In vitro; Biological activity; Medicinal plant; Antifungal agent; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Isolation; Lignan; Spermatophyta; Benzofuran derivatives; Antibacterial agent
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)00225-9

Chemical examination of the leaves of Styrax ferrugineus yielded 5-[3″-(β- d-glucopyranosyloxy)propyl]-7-methoxy-2-(3′,4′-dimethoxyphenyl) benzofuran, along with the known nor-lignans 5-(3″-hydroxypropyl)-7-methoxy-2-(3′,4′-methylenedioxyphenyl)benzofuran, 5-(3″-hydroxypropyl)-7-methoxy-2-(3′,4′-dimethoxyphenyl)benzofuran, 5-[3″-(β- d-glucopyranosyloxy)propyl]-7-methoxy-2-(3′,4′-methylenedioxyphenyl)benzofuran and the lignan, dihydrodehydrodiconiferyl alcohol. All arylpropanoids isolated showed antibacterial and antifungal activities. The structures of the isolates were established by spectroscopic analysis.