Fabrication of Scaffolds for Bone-Tissue Regeneration

The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bo...

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Published in	Materials Vol. 12; no. 4; p. 568
Main Authors	Chocholata, Petra, Kulda, Vlastimil, Babuska, Vaclav
Format	Journal Article
Language	English
Published	Switzerland MDPI AG 14.02.2019 MDPI
Subjects	Biological properties Biomedical materials Bones Cell adhesion & migration Chemical properties Collagen Defects Dental implants Dental materials Dentin Fractures Growth factors Immunology Life sciences Mammals Membranes Mineralization Organic chemistry Osteoblasts Regeneration (physiology) Review Stem cells Surgical implants Tissue engineering Transplants & implants stem cells hydrogels scaffolds bone tissue engineering regenerative medicine
Online Access	Get full text
ISSN	1996-1944 1996-1944
DOI	10.3390/ma12040568

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Abstract	The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.
AbstractList	The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration. The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration. The term “tissue engineering”, where engineering and the life sciences are interconnected, was introduced in 1988 in the National Science Foundation workshop as “the application of principles and methods of engineering and life sciences towards the fundamental understanding of structure–function relationships in normal and pathological mammalian tissues and the development of biological substitutes to restore, maintain or improve tissue function.” GBR, also called “membrane protected bone regeneration” [17], uses barrier membranes in the treatment of alveolar ridge defects and promotes bone growth into tissue defects adjacent to dental implants. The mechanical, biological and chemical properties and functions of bones depend on the irregular but optimized structure, making bone material heterogeneous and anisotropic, as can be seen at different levels (Figure 1) [18,19]. Osteoblasts, Osteocytes, Osteoclasts and Bone-Lining Cells During life, two inseparable processes—bone resorbing by osteoclasts and bone formation by osteoblasts—happen alongside remodeling of the skeleton with optimal mechanical integrity.
Author	Chocholata, Petra Babuska, Vaclav Kulda, Vlastimil
AuthorAffiliation	Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic; petra.chocholata@lfp.cuni.cz (P.C.); vlastimil.kulda@lfp.cuni.cz (V.K.)
AuthorAffiliation_xml	– name: Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Pilsen, Czech Republic; petra.chocholata@lfp.cuni.cz (P.C.); vlastimil.kulda@lfp.cuni.cz (V.K.)
Author_xml	– sequence: 1 givenname: Petra orcidid: 0000-0001-9519-2292 surname: Chocholata fullname: Chocholata, Petra – sequence: 2 givenname: Vlastimil orcidid: 0000-0001-7926-994X surname: Kulda fullname: Kulda, Vlastimil – sequence: 3 givenname: Vaclav orcidid: 0000-0001-9296-9414 surname: Babuska fullname: Babuska, Vaclav
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30769821$$D View this record in MEDLINE/PubMed
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Snippet	The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material... The term “tissue engineering”, where engineering and the life sciences are interconnected, was introduced in 1988 in the National Science Foundation workshop...
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SubjectTerms	Biological properties Biomedical materials Bones Cell adhesion & migration Chemical properties Collagen Defects Dental implants Dental materials Dentin Fractures Growth factors Immunology Life sciences Mammals Membranes Mineralization Organic chemistry Osteoblasts Regeneration (physiology) Review Stem cells Surgical implants Tissue engineering Transplants & implants
Title	Fabrication of Scaffolds for Bone-Tissue Regeneration
URI	https://www.ncbi.nlm.nih.gov/pubmed/30769821 https://www.proquest.com/docview/2333492127 https://www.proquest.com/docview/2201716322 https://pubmed.ncbi.nlm.nih.gov/PMC6416573
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