New sinularianin sesquiterpenes from soft coral Sinularia sp

Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compou...

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Published inMarine drugs Vol. 11; no. 12; pp. 4741 - 4750
Main Authors Yang, Bin, Liao, Shengrong, Lin, Xiuping, Wang, Junfeng, Liu, Juan, Zhou, Xuefeng, Yang, Xianwen, Liu, Yonghong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.12.2013
MDPI
Subjects
Animals
Anthozoa - chemistry
Cell Line
China
HEK293 Cells
Humans
NF-kappa B - metabolism
NF-κB
Oceans and Seas
sesquiterpenes
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Sinularia sp
sinularianins
soft coral
China
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Summary:Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1660-3397
1660-3397
DOI:10.3390/md11124741