DNA interaction networks： an information highway for regulated gene expression in the 3-dimentional space of the nucleus

• Published in: Cell research Vol. 19; no. 12; pp. 1316 - 1319
• Main Authors: Wang, Dong, Fu, Xiang-Dong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2009; Nature Publishing Group
• Subjects: Animals; Biological Assay - methods; Biological Assay - trends; Biomedical and Life Sciences; CCCTC-Binding Factor; Cell Biology; Cell Nucleus - genetics; Chromosome Mapping - methods; Chromosome Mapping - trends; Chromosomes - genetics; DNA; DNA - genetics; DNA-Binding Proteins - genetics; Gene Expression Regulation - genetics; Humans; Insulator Elements - genetics; Life Sciences; Molecular Biology - methods; Molecular Biology - trends; Regulatory Elements, Transcriptional - genetics; Repressor Proteins - genetics; research-highlight; Transcriptional Activation - genetics; 三维空间; 信息高速公路; 基因表达; 基因转录; 基础研究; 相互作用
• ISSN: 1001-0602; 1748-7838; 1748-7838
• DOI: 10.1038/cr.2009.133

In this genomic era, the research landscape has been taking a dramatic turn in discovering new biological principles that have been unapproachable from traditional studies on the basis of individual genes and this process is accelerating because of technological breakthroughs, largely fueled by the next generation sequencing. Many years of research have established a dogmatic view on transcription that gene promoters drive transcriptional initiation, which is subject to modulation by distal enhancers .