Protective Effects of 3,4-Oxo-isopropylidene-Shikimic Acid on Experimental Colitis Induced by Trinitrobenzenesulfonic Acid in Rats

• Published in: Digestive diseases and sciences Vol. 57; no. 8; pp. 2045 - 2054
• Main Authors: Xing, Jian-Feng, Sun, Jian-Ning, Sun, Jin-Yao, You, Cui-Yu, Dong, Kai, Lv, Jun, Dong, Ya-Lin
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.08.2012; Springer; Springer Nature B.V
• Subjects: Animals; Biochemistry; Colitis; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - pathology; Colon - immunology; Colon - metabolism; Colon - pathology; Disease Models, Animal; Drug Evaluation, Preclinical; Gastroenterology; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Hepatology; Illicium; Inflammation; Insomnia; Male; Malondialdehyde - metabolism; Medicine; Medicine & Public Health; Medicine, Chinese; Neutrophil Infiltration; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Oncology; Original Article; Rats; Rats, Sprague-Dawley; Resveratrol; Shikimic Acid - analogs & derivatives; Shikimic Acid - pharmacology; Shikimic Acid - therapeutic use; Skin; Superoxide; Superoxide Dismutase - metabolism; Transplant Surgery; Trinitrobenzenesulfonic Acid; Experimental colitis; 3,4-Oxo-isopropylidene-shikimic acid; 2,4,6-Trinitrobenzenesulfonic acid; Antioxidation

Background 3,4-Oxo-isopropylidene-shikimic acid (ISA) is a derivative of shikimic acid (SA). SA is extracted from Illicium verum Hook.fil., which has been used in traditional Chinese medicine and used for treating vomiting, stomach aches, insomnia, skin inflammation, and rheumatic pain. Aims To inve...