Eight new peptaibols from sponge-associated Trichoderma atroviride

Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dim...

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Published inMarine drugs Vol. 11; no. 12; pp. 4937 - 4960
Main Authors Panizel, Irina, Yarden, Oded, Ilan, Micha, Carmeli, Shmuel
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.12.2013
MDPI
Subjects
Aminoisobutyric Acids - chemistry
Aminoisobutyric Acids - pharmacokinetics
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Axinella polypoides
Axinella verrucosa
Bacteria - drug effects
Hydrophobic and Hydrophilic Interactions
peptaibols
Peptaibols - chemistry
Peptaibols - pharmacology
Peptides - chemistry
Porifera - chemistry
Trichoderma - chemistry
Trichoderma atroviride
trichorzianines
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Summary:Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel.
ISSN:1660-3397
1660-3397
DOI:10.3390/md11124937