How Common Are Extraribosomal Functions of Ribosomal Proteins?

Ribosomal proteins are ubiquitous, abundant, and RNA binding: prime candidates for recruitment to extraribosomal functions. Indeed, they participate in balancing the synthesis of the RNA and protein components of the ribosome itself. An exciting new story is that ribosomal proteins are sentinels for...

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Bibliographic Details
Published inMolecular cell Vol. 34; no. 1; pp. 3 - 11
Main Authors Warner, Jonathan R., McIntosh, Kerri B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.04.2009
Subjects
Apoptosis - physiology
Neoplasms - metabolism
Ribosomal Proteins - genetics
Ribosomal Proteins - metabolism
Ribosomal Proteins - physiology
Ribosomes - metabolism
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
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Summary:Ribosomal proteins are ubiquitous, abundant, and RNA binding: prime candidates for recruitment to extraribosomal functions. Indeed, they participate in balancing the synthesis of the RNA and protein components of the ribosome itself. An exciting new story is that ribosomal proteins are sentinels for the self-evaluation of cellular health. Perturbation of ribosome synthesis frees ribosomal proteins to interface with the p53 system, leading to cell-cycle arrest or to apoptosis. Yet in only a few cases can we clearly identify the recruitment of ribosomal proteins for other extraribosomal functions. Is this due to a lack of imaginative evolution by cells and viruses, or to a lack of imaginative experiments by molecular biologists?
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2009.03.006