Metal–organic frameworks: advanced tools for multicomponent reactions
The increasing demand for simple, clean, and sustainable protocols for the preparation of complex organic molecules has continuously encouraged researchers to discover and design modern methodologies. Metal-catalyzed multicomponent reactions (MCRs) are versatile synthetic protocols frequently utiliz...
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| Published in | Green Chemistry Vol. 22; no. 21; pp. 7265 - 7300 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge
Royal Society of Chemistry (RSC)
01.01.2020
Royal Society of Chemistry |
| Subjects | |
| Online Access | Get full text |
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| Summary: | The increasing demand for simple, clean, and sustainable protocols for the preparation of complex organic molecules has continuously encouraged researchers to discover and design modern methodologies. Metal-catalyzed multicomponent reactions (MCRs) are versatile synthetic protocols frequently utilized in the preparation of numerous natural products and pharmaceuticals, offering perfect molecular diversity and high level of atom efficiency with energy saving in a single reaction step. Although most of the investigated metal-catalyzed MCRs are based on transition metal catalysts such as palladium and copper, the exploration of new sustainable catalytic systems is constantly the subject of intense research. In this regard, metal-organic frameworks (MOFs) have recently drawn significant interest as environmentally benign alternatives, providing abundant catalytic sites in highly ordered crystalline skeletons. Although this field of research is still in its infancy, MOFs have clearly exhibited their efficacy in multicomponent reactions. This review aims to outline the developments of MOFs for benign applications in multicomponent reactions.
Metal-organic frameworks (MOFs) offering abundant catalytic sites in highly ordered crystalline skeletons have recently received considerable attention as green platforms for multicomponent reactions, which are discussed in this review. |
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| Bibliography: | Farzad Zamani received his M.Sc. in Organic Chemistry from Islamic Azad University (Iran) in 2009. He then worked as a research assistant at the Isfahan Science and Technology Town at Isfahan University of Technology, focusing on heterogeneous catalysis. He completed his Ph.D. at the University of Wollongong (Australia) in 2019 under the supervision of Professor Stephen Pyne and Associate Professor Christopher Hyland, where he specialised in transition metal-catalysed cyclization reactions and heterocycle synthesis. He is currently a JSPS postdoctoral fellow in the group of Professor Takayoshi Suzuki at Osaka University, focusing on the synthesis of small molecule RNA inhibitors in drug discovery. multicomponent reactions. Mohammad Ali Ghasemzadeh received his B.Sc. and M.Sc. degrees in Chemistry and Organic Chemistry from the University of Kashan (Iran) in 2005 and 2008, respectively. He completed his Ph.D. in Organic Chemistry from the University of Kashan, under the supervision of Professor Javad Safaei-Ghomi in 2012. He then joined the Department of Chemistry at Islamic Azad University (Qom Branch, Iran) as an Assistant Professor, where he and his group are now based. His research group specializes in functionalized metal nanostructures, metal-organic frameworks and supported ionic liquids as catalysts for the synthesis of heterocyclic compounds multicomponent reactions in the presence of heterogeneous nanostructures. Boshra Mirhosseini-Eshkevari received her B.Sc. degree in Chemistry from Islamic Azad University (Qom Branch, Iran) in 2012 and her M.Sc. degree in Organic Chemistry from the same university under the supervision of Dr Mohammad Ali Ghasemzadeh in 2014. She obtained her Ph.D. in Organic Chemistry from Islamic Azad University (Tehran North Branch, Iran) under the supervision of Dr Manzarbanoo Esnaashari and Dr Mohammad Ali Ghasemzadeh in 2020. Her Ph.D. research focused on the synthesis and application of heterogeneous nanocatalysts and metal-organic frameworks in multicomponent reactions. Mona Tavakoli received her B.Sc. and M.Sc. degrees in Chemistry and Organic Chemistry from Islamic Azad University (Qom Branch, Iran) in 2012 and 2014, respectively. She obtained her Ph.D. in Organic Chemistry from the University of Kashan (Iran) under the supervision of Professor Javad Safari and Dr Mohammad Ali Ghasemzadeh in 2019. Her research interests include synthesis of heterocyclic compounds via ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 1463-9262 1463-9270 1463-9270 |
| DOI: | 10.1039/d0gc01767a |