Antioxidant, cytotoxic and genotoxic evaluation of alcoholic extract of Polyalthia cerasoides (Roxb.) Bedd

Abstract Antioxidative potential of alcohol extract of Polyalthia cerasoides was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, superoxide anion scavenging, and reducing power assays were performed. The extract showed significant reactive oxygen species (ROS) scavenging acti...

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Published inEnvironmental toxicology and pharmacology Vol. 26; no. 2; pp. 142 - 146
Main Authors Ravikumar, Y.S, Mahadevan, K.M, Kumaraswamy, M.N, Vaidya, V.P, Manjunatha, H, Kumar, V, Satyanarayana, N.D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2008
Subjects
Annonaceae
Chromosomal aberration
Emergency
Free radical
Medicinal plants
MTT assay
Medicinal plants
Chromosomal aberration
Annonaceae
MTT assay
Free radical
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Summary:Abstract Antioxidative potential of alcohol extract of Polyalthia cerasoides was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical, superoxide anion scavenging, and reducing power assays were performed. The extract showed significant reactive oxygen species (ROS) scavenging activity in all in vitro antioxidant assays and contained high level of total phenolic content. For in vivo genotoxic evaluation, Swiss albino mice were treated with alcohol extract at the concentration of 40 mg/kg body weight. Frequency of aberration was compared with control. Both the sets did not showed genotoxic effect. Further the extract was subjected to cytotoxic study using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) assay, the extract confirmed to show moderate cytotoxicity against L929 cell line.
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ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2008.03.001