Use of an Extract of Annona muricata Linn to Prevent High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice

• Published in: Nutrients Vol. 11; no. 7; p. 1509
• Main Authors: Sasso, Sandramara, Sampaio E Souza, Priscilla Cristovam, Santana, Lidiani Figueiredo, Cardoso, Claudia Andréa Lima, Alves, Flávio Macedo, Portugal, Luciane Candeloro, de Faria, Bernardo Bacelar, da Silva, Anderson Fernandes, Motta-Castro, Ana Rita Coimbra, Soares, Luana Silva, Bandeira, Larissa Melo, Guimarães, Rita de Cássia Avellaneda, Freitas, Karine de Cássia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.07.2019; MDPI
• Subjects: Adiposity - drug effects; Alkaloids; Animals; Annona - chemistry; Annona muricata; Anti-Obesity Agents - isolation & purification; Anti-Obesity Agents - pharmacology; Anti-Obesity Agents - toxicity; Biomarkers - blood; Blood Glucose - drug effects; Blood Glucose - metabolism; Body weight; Carbohydrates; Chemical composition; Chromatography; Complications; Cytokines; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diet, High-Fat; Dietary fiber; Disease Models, Animal; Female; Flavonoids; Food; Glucose; Glucose Metabolism Disorders - blood; Glucose Metabolism Disorders - drug therapy; Glucose Metabolism Disorders - physiopathology; graviola; Herbal medicine; High fat diet; Hypocaloric diet; Inflammation Mediators - blood; Insulin; Insulin Resistance; Laboratories; Leaves; Lipids - blood; Lipoproteins; Male; Metabolic disorders; Metabolism; Mice, Inbred C57BL; Nutrition; Obesity; Obesity - blood; Obesity - drug therapy; Obesity - physiopathology; Organic chemistry; Pharmaceutical sciences; Phenols; Phytosterols; Plant extracts; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - toxicity; Plant Leaves; Rats, Wistar; Saponins; Streptozocin; Tannins; Tea; Tumor necrosis factor-TNF; Weight control; Weight Gain - drug effects; weight loss; Weight reduction; Brazil; United States > US; weight loss; graviola; obesity
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11071509

Linn, commonly known as graviola, is one of the most popular plants used in Brazil for weight loss. The aim of this study is to evaluate the therapeutic effects of three different doses (50 mg/kg, 100 mg/kg, and 150 mg/kg) of aqueous graviola leaf extract (AGE) supplemented by oral gavage, on obese C57BL/6 mice. Food intake, body weight, an oral glucose tolerance test (OGTT), an insulin sensitivity test, quantification of adipose tissue cytokines, weight of fat pads, and serum biochemical and histological analyses of the liver, pancreas, and epididymal adipose tissue were measured. AGE had an anti-inflammatory effect by increasing IL-10 at doses of 50 and 100 mg/kg. Regarding the cholesterol profile, there was a significant decrease in LDL-cholesterol levels in the AGE 150 group, and VLDL-cholesterol and triglycerides in the AGE 100 and 150 groups. There was an increase in HDL cholesterol in the AGE 150 group. The extract was able to reduce the adipocyte area of the epididymal adipose tissue in the AGE 100 and 150 groups. According to the histological analysis of the liver and pancreas, no significant difference was found among the groups. There were no significant effects of AGE on OGTT and serum fasting glucose concentration. However, the extract was effective in improving glucose tolerance in the AGE 150 group.