Elevated Coagulation Factor VIII Plasma Activity in a Patient with Lymphangiosarcoma

• Published in: Internal Medicine Vol. 51; no. 22; pp. 3213 - 3215
• Main Authors: Yamane, Hiromichi, Ochi, Nobuaki, Tabayashi, Takayuki, Lu, Lu, Yamagishi, Tomoko, Monobe, Yasumasa, Tanaka, Takehiro, Kondoh, Eisei, Takigawa, Nagio
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2012
• Subjects: Aged; cervical cancer; chronic lymph edema; Factor VIII - metabolism; factor VIII-related antigen; Fatal Outcome; Female; Humans; Immunohistochemistry; lymphangiosarcoma; Lymphangiosarcoma - blood; Lymphangiosarcoma - diagnosis; Lymphangiosarcoma - etiology; Lymphangiosarcoma - immunology; Lymphedema - complications; Thigh; Uterine Cervical Neoplasms - complications; von Willebrand Factor - metabolism
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.51.8083

A 72-year-old woman was referred to our hospital for palliative care. Fifteen years earlier, she had undergone total hysterectomy and radiotherapy for cervical cancer. One year before her referral, she visited a hospital due to a gait disturbance and was diagnosed with lymphangiosarcoma. The level of coagulation factor VIII plasma activity was >201% (normal range: 62-145%) and the immunohistochemical results were positive for factor VIII-related antigen in a tumor specimen. To the best of our knowledge, this is the first report of high coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.