Vitamin D Status and Gastric Cancer: A Cross-Sectional Study in Koreans

• Published in: Nutrients Vol. 12; no. 7; p. 2004
• Main Authors: Kwak, Jung Hyun, Paik, Jean Kyung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.07.2020; MDPI
• Subjects: 25-Hydroxyvitamin D; Adult; Adults; Age; Alcohol; Angiogenesis; Apoptosis; Blood pressure; Body mass; Body mass index; Body size; Calciferol; Carcinogenesis; Carcinogens; Confidence intervals; Cross-Sectional Studies; cross-sectional study; Education; Energy; Family income; Female; Gastric cancer; Households; Humans; Infections; KNHANES; Korea; Male; Males; Metastasis; Middle Aged; Nutrition Surveys; Population; Prevalence; Questionnaires; Republic of Korea; Statistical analysis; Stomach Neoplasms - epidemiology; Vitamin A; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin deficiency; Republic of Korea; United States > US; KNHANES; cross-sectional study; gastric cancer; vitamin D; Korea
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12072004

Sufficient vitamin D levels are associated with reduced infections, which can cause gastric carcinogenesis. We examined associations between vitamin D concentrations and gastric cancer (GC) prevalence in a Korean population. We analyzed data of 33,119 adults using serum 25-hydroxyvitamin D (25(OH)D) concentrations as a biomarker of vitamin D status. Participants were classified with GC if previously diagnosed as such by a physician. After controlling for age, sex and body mass index (model A), odds ratio (OR) for GC was 0.81 (95% confidence interval [CI]: 0.70, 0.95), with a 5-ng/mL increment in total 25(OH)D concentrations. In fully adjusted models (model B), the OR for GC was 0.84 (95% CI: 0.72, 0.98), with a 5-ng/mL increment in total vitamin D. Following the classification of vitamin D concentrations into three categories or for GC in model A was 0.52 (95% CI: 0.30, 0.92) comparing between higher (≥20 ng/mL) and lower (<12 ng/mL) total 25(OH)D concentrations. In model B OR for GC was 0.57 (95% CI: 0.32, 1.00) comparing between higher and lower total 25(OH)D concentrations. Our results suggested that high vitamin D concentration was associated with lower ORs of GC in Korean adults.