A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor

In this study, biosensors based on zinc oxide⁻copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surface...

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Published inMaterials Vol. 12; no. 7; p. 1126
Main Authors Cao, Lu, Kiely, Janice, Piano, Martina, Luxton, Richard
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.04.2019
MDPI
Subjects
Antibodies
Atomic force microscopy
biosensor
Biosensors
Copper oxides
CRP
Glass substrates
impedance
Nanocrystals
Nanomaterials
Nanoparticles
Nanowires
Polyethylene terephthalate
Proteins
Raman spectroscopy
Sensors
Software
Spectrum analysis
Zinc oxide
Zinc oxides
ZnO–CuO
United Kingdom > UK
United States > US
CRP
ZnO–CuO
impedance
biosensor
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Summary:In this study, biosensors based on zinc oxide⁻copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO⁻CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface.
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ISSN:1996-1944
1996-1944
DOI:10.3390/ma12071126