Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431

• Published in: Marine drugs Vol. 17; no. 3; p. 182
• Main Authors: Guo, Heng, Liu, Zhao-Ming, Chen, Yu-Chan, Tan, Hai-Bo, Li, Sai-Ni, Li, Hao-Hua, Gao, Xiao-Xia, Liu, Hong-Xin, Zhang, Wei-Min
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.03.2019; MDPI
• Subjects: Acids; Analytical methods; Aquatic Organisms - chemistry; Beta decay; Cancer; Carbon; Cell Line, Tumor; Cell lines; chromone-derived polyketides; Chromones - chemistry; Crystallography; Crystallography, X-Ray; Cytotoxicity; Deep sea; Deep sea environments; Deep water; deep-sea derived fungus; Diaporthe; Diaporthe phaseolorum; Drug Screening Assays, Antitumor; Electron capture; Fungi; Fungi - chemistry; Humans; Hydrocarbons; Ionization; Kinases; Magnetic Resonance Spectroscopy; Mass spectroscopy; Molecular Structure; Natural products; NMR; Nuclear magnetic resonance; phaseolorins A-F; Polyketides; Polyketides - chemistry; Polyketides - isolation & purification; Polyketides - pharmacology; Spectrometry, Mass, Electrospray Ionization; Tumor cell lines; X-ray crystallography; deep-sea derived fungus; chromone-derived polyketides; phaseolorins A-F; Diaporthe phaseolorum
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md17030182

Five new chromone-derived polyketides phaseolorins A-F ( ⁻ ), together with nine known compounds, were isolated from the deep-sea derived fungus FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member -lactone ring. Moreover, the new compounds ( ⁻ ) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.