Apoptosis-induced lymphopenia in sepsis and other severe injuries

Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries, are usually followed by a period of marked immunosuppression. In particular, while lymphocytes play a pivotal role in immune response, their functions and numbers are profoundly altered after severe injuries....

Full description

Saved in:
Bibliographic Details
Published inApoptosis (London) Vol. 22; no. 2; pp. 295 - 305
Main Authors Girardot, Thibaut, Rimmelé, Thomas, Venet, Fabienne, Monneret, Guillaume
Format Journal Article Book Review
LanguageEnglish
Published New York Springer US 01.02.2017
Springer
Springer Nature B.V
Subjects
Apoptosis
Apoptosis - genetics
Biochemistry
Biomedical and Life Sciences
Biomedicine
Burns - genetics
Burns - pathology
Cancer Research
Cell Biology
Health aspects
Health risks
Hospital patients
Humans
Immune response
Immune Tolerance - genetics
Immunotherapy
Injuries
Lymphocytes
Lymphocytes - metabolism
Lymphocytes - pathology
Lymphocytopenia
Lymphopenia - etiology
Lymphopenia - genetics
Lymphopenia - pathology
Oncology
Physiological aspects
Review
Sepsis - complications
Sepsis - genetics
Sepsis - pathology
Virology
Lymphocytes
Injury
Surgery
Sepsis
Burns
Trauma
Apoptosis
Online AccessGet full text

Cover

More Information
Summary:Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries, are usually followed by a period of marked immunosuppression. In particular, while lymphocytes play a pivotal role in immune response, their functions and numbers are profoundly altered after severe injuries. Apoptosis plays a central role in this process by affecting immune response at various levels. Indeed, apoptosis-induced lymphopenia duration and depth have been associated with higher risk of infection and mortality in various clinical settings. Therapies modulating apoptosis represent an interesting approach to restore immune competence after acute injury, although their use in clinical practice still presents several limitations. After briefly describing the apoptosis process in physiology and during severe injuries, we will explore the immunological consequences of injury-induced lymphocyte apoptosis, and describe associations with clinically relevant outcomes in patients. Therapeutic perspectives targeting apoptosis will also be discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1360-8185
1573-675X
DOI:10.1007/s10495-016-1325-3