Palladium-based nanomaterials for cancer imaging and therapy

• Published in: Theranostics Vol. 10; no. 22; pp. 10057 - 10074
• Main Authors: Liu, Yongchun, Li, Jingchao, Chen, Mei, Chen, Xiaolan, Zheng, Nanfeng
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animals; Biocompatibility; Cancer therapies; Chemotherapy; Contrast agents; Contrast Media - administration & dosage; Copyright; Diagnostic Imaging - methods; Efficiency; Humans; Lasers; Morphology; Nanomaterials; Nanostructures - chemistry; Neoplasms - diagnostic imaging; Neoplasms - therapy; Palladium; Palladium - chemistry; Phototherapy - methods; Research Paper; combined cancer therapy; safety profile; Palladium-based nanomaterials; cancer imaging; photothermal therapy
• DOI: 10.7150/thno.45990
• ISSN: 1838-7640

In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensive and critical perspective on the recent progress of Pd-based nanomaterials as imaging contrast agents and therapeutic agents. The imaging section focuses on applications in photoacoustic (PA) imaging, single-photon emission computed tomography (SPECT) imaging, computed tomography (CT) imaging and magnetic resonance (MR) imaging. For treatment of cancer, single photothermal therapy (PTT) and PTT combined with other therapeutic modalities will be discussed. Finally, the safety concerns, forthcoming challenges and perspective of Pd-based nanomaterials on biomedical applications will be presented.