Palladium-based nanomaterials for cancer imaging and therapy

In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials,...

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Published inTheranostics Vol. 10; no. 22; pp. 10057 - 10074
Main Authors Liu, Yongchun, Li, Jingchao, Chen, Mei, Chen, Xiaolan, Zheng, Nanfeng
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2020
Ivyspring International Publisher
Subjects
Animals
Biocompatibility
Cancer therapies
Chemotherapy
Contrast agents
Contrast Media - administration & dosage
Copyright
Diagnostic Imaging - methods
Efficiency
Humans
Lasers
Morphology
Nanomaterials
Nanostructures - chemistry
Neoplasms - diagnostic imaging
Neoplasms - therapy
Palladium
Palladium - chemistry
Phototherapy - methods
Research Paper
combined cancer therapy
safety profile
Palladium-based nanomaterials
cancer imaging
photothermal therapy
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Summary:In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensive and critical perspective on the recent progress of Pd-based nanomaterials as imaging contrast agents and therapeutic agents. The imaging section focuses on applications in photoacoustic (PA) imaging, single-photon emission computed tomography (SPECT) imaging, computed tomography (CT) imaging and magnetic resonance (MR) imaging. For treatment of cancer, single photothermal therapy (PTT) and PTT combined with other therapeutic modalities will be discussed. Finally, the safety concerns, forthcoming challenges and perspective of Pd-based nanomaterials on biomedical applications will be presented.
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These authors contributed equally to this work.
Competing Interests: The authors have declared that no competing interest exists.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.45990