Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

• Published in: Theranostics Vol. 10; no. 18; pp. 8315 - 8342
• Main Authors: Zhang, Jin, Xiang, Honggang, Liu, Jie, Chen, Yi, He, Rong-Rong, Liu, Bo
• Format: Journal Article Book Review
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Acetylation - drug effects; Aging; Aging - drug effects; Aging - metabolism; Amino acids; Apoptosis; Autophagy; Binding sites; Cancer; Cardiovascular disease; Cell cycle; DNA repair; Drug Discovery; Fatty acids; Gene expression; Heart Diseases - drug therapy; Heart Diseases - metabolism; Homeostasis; Humans; Inflammation; Kidney diseases; Liver diseases; Localization; Mammals; Metabolic Diseases - drug therapy; Metabolic Diseases - metabolism; Metabolic disorders; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Molecular Targeted Therapy - methods; Neoplasms - drug therapy; Neoplasms - metabolism; Neurodegeneration; Oxidation; Oxidative stress; Proteins; Regulation B; Regulation D; Review; Sirtuin 3 - antagonists & inhibitors; Sirtuin 3 - metabolism; SIRT3 activator; Age-related disease; Mitochondrial homeostasis; SIRT3 inhibitor; Cancer; SIRT3
• ISSN: 1838-7640; 1838-7640
• DOI: 10.7150/thno.45922

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. Hitherto, SIRT3 has been substantiated to be involved in almost all aspects of mitochondrial metabolism and homeostasis, protecting mitochondria from a variety of damage. Accumulating evidence has recently documented that SIRT3 is associated with many types of human diseases, including age-related diseases, cancer, heart disease and metabolic diseases, indicating that SIRT3 can be a potential therapeutic target. Here we focus on summarizing the intricate mechanisms of SIRT3 in human diseases, and recent notable advances in the field of small-molecule activators or inhibitors targeting SIRT3 as well as their potential therapeutic applications for future drug discovery.