Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp

Analysis of the chemical components from the culture broth of the marine bacterium sp. CNQ-490 has yielded three novel compounds: saccharobisindole ( ), neoasterric methyl ester ( ), and 7-chloro-4( )-quinolone ( ), in addition to acremonidine E ( ), pinselin ( ), penicitrinon A ( ), and penicitrino...

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Published inMarine drugs Vol. 20; no. 1; p. 35
Main Authors Kim, Sohee, Le, Tu Cam, Han, Sang-Ah, Hillman, Prima F, Hong, Ahreum, Hwang, Sunghoon, Du, Young Eun, Kim, Hiyoung, Oh, Dong-Chan, Cha, Sun-Shin, Lee, Jihye, Nam, Sang-Jip, Fenical, William
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.12.2021
MDPI
Subjects
Actinobacteria
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibacterial activity
Antibiotics
Aquatic Organisms
Bacillus subtilis - drug effects
Bacteria
Carbon
Esters
Humans
Hydrocarbons
marine natural products
Mass spectrometry
Mass spectroscopy
Metabolites
Microbial Sensitivity Tests
NMR
Nuclear magnetic resonance
Quinolones - chemistry
Quinolones - pharmacology
Quorum sensing
Saccharomonospora sp
Scientific imaging
Staphylococcus aureus
antibacterial activity
Saccharomonospora sp
marine natural products
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Summary:Analysis of the chemical components from the culture broth of the marine bacterium sp. CNQ-490 has yielded three novel compounds: saccharobisindole ( ), neoasterric methyl ester ( ), and 7-chloro-4( )-quinolone ( ), in addition to acremonidine E ( ), pinselin ( ), penicitrinon A ( ), and penicitrinon E ( ). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound generated weak inhibition activity against KCTC2441 and KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds and did not have any observable effects. In addition, compound displayed weak anti-quorum sensing (QS) effects against KCTC1927 and SCO560.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20010035