Association of biological markers of activity of systemic lupus erythematosus with levels of anti-oxidized low-density lipoprotein antibodies

• Published in: Rheumatology (Oxford, England) Vol. 43; no. 4; pp. 510 - 513
• Main Authors: Gómez-Zumaquero, J. M., Tinahones, F. J., De Ramón, E., Camps, M., Garrido, L., Soriguer, F. J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2004; Oxford Publishing Limited (England)
• Subjects: Activity markers; Autoantibodies - blood; Biological and medical sciences; Biomarkers - blood; Complement Activation; Complement C4 - metabolism; Diseases of the osteoarticular system; Follow-Up Studies; Humans; Immunoglobulin G - blood; Linear Models; Lipoproteins, LDL - immunology; Lupus Erythematosus, Systemic - immunology; Medical sciences; Oxidized LDL antibodies; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severity of Illness Index; Systemic lupus erythematosus; Immunopathology; Connective tissue disease; Skin disease; Antibody; Rheumatology; Biological marker; Autoimmune disease; Lipoprotein; Density; Oxidized LDL antibodies; Biological activity; Association; Systemic lupus erythematosus; Activity markers; Low; Systemic disease
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/keh109

Objectives. To study the levels of anti-oxidized low-density lipoprotein (LDL) antibodies in patients with systemic lupus erythematosus (SLE) at two different points during the disease, and evaluate their relation with markers of SLE activity in serial blood samples. To investigate the correlations at two points in time between anti-oxidized LDL antibodies and anti-β2-glycoprotein-I antibodies, leucocytes, immunoglobulin G, anti-deoxyribonucleic acid, complement 3, complement 4 and the disease activity index. Methods. A total of 49 patients with SLE according to ACR criteria were studied at two points, 3 to 4 months apart, Time 1 and Time 2. Results. There were ostensible changes in levels of anti-oxidized LDL antibodies between Times 1 and 2, which correlated significantly with disease activity markers. The association between levels of anti-oxidized LDL antibodies and complement system activation remained after multiple regression analysis with stepwise adjustment. Conclusions. Antibody levels against oxidized LDL vary with time and are closely related to the degree of SLE activity. There is an association between levels of autoantibodies to oxidized LDL and complement system activation.