Effects of a new injectable short-term release deslorelin in foal-heat mares

• Published in: Theriogenology Vol. 62; no. 5; pp. 831 - 836
• Main Authors: Stich, K.L, Wendt, K.M, Blanchard, T.L, Brinsko, S.P
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2004
• Subjects: Animals; Breeding; Deslorelin; diameter; Drug Implants; estrus; Estrus - drug effects; Female; female fertility; Fertility; GnRH; gonadotropin-releasing hormone; Graafian follicles; hormone agonists; Horses - physiology; Injections; intramuscular injection; Mare; mares; natural mating; Ovarian Follicle - anatomy & histology; Ovarian Follicle - drug effects; ovulation; Ovulation Induction - veterinary; Postpartum estrus; postpartum interval; Postpartum Period; Pregnancy; pregnancy rate; Triptorelin Pamoate - administration & dosage; Triptorelin Pamoate - adverse effects; Triptorelin Pamoate - analogs & derivatives; Ultrasonography - veterinary; Texas; Deslorelin; Mare; GnRH; Fertility; Postpartum estrus
• ISSN: 0093-691X; 1879-3231
• DOI: 10.1016/j.theriogenology.2003.12.004

Mares treated with subcutaneous deslorelin implants on the first postpartum estrus early in the breeding season had significant reductions in the number of large follicles at early pregnancy examinations and delayed return to estrus (in mares that failed to become pregnant); these adverse effects were attributed to a prolonged release of the drug from the implant. In 2003, an injectable short-term release (<24 h) deslorelin product became available. The objective of this study was to determine if this product would hasten ovulation in early foaling first postpartum estrus mares without reducing the number of large follicles at early pregnancy examination (14–15 days postovulation). Beginning 5–6 days postpartum, first postpartum estrus (foal-heat) mares were teased daily and examined thrice weekly (Tuesday, Thursday and Saturday) by transrectal ultrasonography. Mares in estrus with a follicle ≥34 mm diameter on Tuesdays or Thursdays were alternately assigned to: Treatment 1, n=17; 1.5 mg injectable short-term release deslorelin, or Treatment 2, n=16; Control (no treatment). The schedule allowed accurate determination of the number of mares ovulating within 2 days of treatment (i.e., ovulations detected on Thursday or Saturday). Mares were mated on the day of treatment and at 2-day intervals until either ovulation was confirmed or until behavioral estrus ceased. Transrectal ultrasonography was done 14–15 days after ovulation to assess ovarian follicles and pregnancy status. Fewer covers were required and more mares ovulated within 2 days of treatment in deslorelin-treated versus Control mares ( P<0.01). Pregnancy rates were normal (69%) in deslorelin-treated mares. The number of large follicles 14–15 days after ovulation did not differ between deslorelin-treated and Control mares ( P>0.10), suggesting follicular suppression did not occur with this formulation of deslorelin.