Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors in diseased regions to increase the specificity of drug delivery. Currently, numerous nanocarriers have been engineered with physicoche...

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Bibliographic Details
Published inTheranostics Vol. 10; no. 10; pp. 4557 - 4588
Main Author Mi, Peng
Format Journal Article Book Review
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2020
Ivyspring International Publisher
Subjects
Antineoplastic Agents - administration & dosage
Cancer therapies
Drug Delivery Systems
Humans
Hydrogen-Ion Concentration
Hypoxia
Immunotherapy - methods
Ligands
Magnetic Fields
Nanoparticles
Nanoparticles - therapeutic use
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
Permeability
Precision Medicine
Review
Tumor Microenvironment
Tumors
Ultrasonic imaging
diagnosis
theranostics
clinical translation
nanoparticles
tumor microenvironment
stimuli-responsive
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Summary:In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors in diseased regions to increase the specificity of drug delivery. Currently, numerous nanocarriers have been engineered with physicochemical changes in responding to external stimuli, such as ultrasound, thermal, light and magnetic field, as well as internal stimuli, including pH, redox potential, hypoxia and enzyme, . Nanocarriers could respond to stimuli in tumor microenvironments or inside cancer cells for on-demanded drug delivery and accumulation, controlled drug release, activation of bioactive compounds, probes and targeting ligands, as well as size, charge and conformation conversion, ., leading to sensing and signaling, overcoming multidrug resistance, accurate diagnosis and precision therapy. This review has summarized the general strategies of developing stimuli-responsive nanocarriers and recent advances, presented their applications in drug delivery, tumor imaging, therapy and theranostics, illustrated the progress of clinical translation and made prospects.
Bibliography:Competing Interests: The authors have declared that no competing interest exists.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.38069