Characterization of Kazachstania slooffiae , a Proposed Commensal in the Porcine Gut

is a fungus commonly isolated from the gastrointestinal tract and feces of post-weaning pigs. Studies have implicated its ability to positively alter piglet gut health through potential symbioses with beneficial bacteria, including and , in providing amino acids as an energy source for microbial and...

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Published inJournal of fungi (Basel) Vol. 7; no. 2; p. 146
Main Authors Summers, Katie Lynn, Foster Frey, Juli, Arfken, Ann M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.02.2021
MDPI
Subjects
Antimicrobial agents
Azoles
Biofilms
Deoxyribonucleic acid
Digestive system
DNA
Echinocandins
Fatty acids
Fungi
Gastrointestinal tract
Genomes
Growth conditions
Hogs
Kazachstania slooffiae
microbiome
mycobiome
Phylogenetics
pig
Polyenes
porcine
swine
Symbiosis
Weaning
United States > US
Enterococcus
swine
mycobiome
porcine
Kazachstania slooffiae
biofilms
microbiome
Lactobacillus
pig
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Summary:is a fungus commonly isolated from the gastrointestinal tract and feces of post-weaning pigs. Studies have implicated its ability to positively alter piglet gut health through potential symbioses with beneficial bacteria, including and , in providing amino acids as an energy source for microbial and piglet growth, and it has been found to be positively correlated with short-chain fatty acids in the piglet gut. However, basic mycological information remains limited, hampering studies. In this study, we characterized the growth parameters, biofilm formation ability, susceptibility to antimicrobials, and genetic relatedness of to other fungal isolates. Optimal fungal growth conditions were determined, no antifungal resistance was found against multiple classes of antifungal drugs (azoles, echinocandins, polyenes, or pyrimidine analogues), and dimorphic growth was observed. produced biofilms that became more complex in the presence of supernatant, suggesting positive interactions with this bacterium in the gut, while supernatant decreased density, suggesting an antagonistic interaction. This study characterizes the growth conditions that are optimal for further studies of , which is an important step in defining the role and interactions of in the porcine gut environment.
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ISSN:2309-608X
2309-608X
DOI:10.3390/jof7020146