Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics

• Published in: Biomaterials Vol. 256; p. 120206
• Main Authors: Duan, Huican, Guo, Haiyan, Zhang, Ruifang, Wang, Fangfang, Liu, Zhuang, Ge, Min, Yu, Luodan, Lin, Han, Chen, Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2020
• Subjects: acidity; biocompatible materials; catalytic activity; disulfides; Exogenous/endogenous-responsiveness; Fenton-like catalysis; glutathione; Humans; Hyperthermia; Hyperthermia, Induced; magnetism; Mn-based nanocatalysis; nanosheets; neoplasms; Neoplasms - therapy; Photonic hyperthermia; Phototherapy; Precision Medicine; Silicene; Theranostic Nanomedicine; toxicity; Tumor Microenvironment; Photonic hyperthermia; Fenton-like catalysis; Exogenous/endogenous-responsiveness; Silicene; Mn-based nanocatalysis
• ISSN: 0142-9612; 1878-5905; 1878-5905
• DOI: 10.1016/j.biomaterials.2020.120206

Silicene as an emerging two-dimensional material (2DM) spurs the broad research interests due to its prominent electronic and physical properties, however, still lacking in exploitation for the biological and medical practices. Herein, we constructed a 2D silicene-based theranostic nanoplatform, MnOx@silicene-BSA (MS-BSA), with tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented catalytic activity when irradiated by near infrared-II (NIR-II) laser because of the high photothermal-conversion efficiency of 2D silicene matrix. Such MS-BSA nanosheets possess the capability to react with glutathione (GSH) to generate Mn2+ and glutathione disulfide (GSSG) under acidity/reducing TME condition. With the presence/assistance of HCO3−, the released Mn2+ exhibited sensitive catalytic activity towards endogenous H2O2via Fenton-like reaction, enabling the generation of highly toxic hydroxyl radicals (•OH), which finally led to the enhanced nanocatalytic therapeutic efficacy followed by exogenous NIR-II laser exposure, originating from hyperthermia-augmented catalytic activity. Especially, these MS-BSA nanosheets accumulated into the tumor region to enable superb contrast enhancement of TME-responsive T1-weighted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), and high-efficient in vivo synergistic tumor eradication. Therefore, such an intelligent photothermal-enhanced catalytic theranostic nanoplatform could realize the exogenous/endogenous-responsive and cooperative hyperthermia-augmented tumor treatment and accurate tumor positioning/monitoring. A 2D silicene-based theranostic nanoplatform, MnOx@silicene-BSA (MS-BSA) has been designed and constructed with tumor exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic activity. Highly dispersed manganese oxide (MnOx) nanoparticles were in-situ grown onto the surface of silicene nanosheets by triggering the redox reaction on 2D surface. After further modification on the surface with bovine serum albumin (BSA), the as-prepared MS-BSA composite nanosheets acted as a multifunctional theranostic nanoplatform that integrated the intriguing multiple performances including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and synergistic photonic hyperthermia and Mn-catalyzed nanocatalytic therapy based on Fenton reaction. [Display omitted]