Recent Advances in miRNA Delivery Systems

MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. MiRNAs hybridize to target mRNA(s) to induce translation repression or mRNA degradation. Functional studies hav...

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Published inMethods and protocols Vol. 4; no. 1; p. 10
Main Authors Dasgupta, Ishani, Chatterjee, Anushila
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.01.2021
MDPI
Subjects
Adenoviruses
Chromosomes
Disease
Gene expression
Genomes
Leukemia
Medical research
MicroRNAs
miRNA
miRNA delivery
miRNA therapeutics
Neuromuscular diseases
Non-coding RNA
non-viral vectors
Post-transcription
viral vectors
Viruses
miRNA therapeutics
miRNA delivery
miRNA
non-viral vectors
viral vectors
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Summary:MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. MiRNAs hybridize to target mRNA(s) to induce translation repression or mRNA degradation. Functional studies have demonstrated that miRNAs are engaged in virtually every physiological process and, consequently, miRNA dysregulations have been linked to multiple human pathologies. Thus, miRNA mimics and anti-miRNAs that restore miRNA expression or downregulate aberrantly expressed miRNAs, respectively, are highly sought-after therapeutic strategies for effective manipulation of miRNA levels. In this regard, carrier vehicles that facilitate proficient and safe delivery of miRNA-based therapeutics are fundamental to the clinical success of these pharmaceuticals. Here, we highlight the strengths and weaknesses of current state-of-the-art viral and non-viral miRNA delivery systems and provide perspective on how these tools can be exploited to improve the outcomes of miRNA-based therapeutics.
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These authors contributed equally to this work.
ISSN:2409-9279
2409-9279
DOI:10.3390/mps4010010