Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease

Currently there is no cure or effective disease-modifying therapy for Alzheimer's disease (AD), the most common form of dementia that is becoming a global threat to public health. It is important to develop novel therapeutic strategies targeting AD pathophysiology particularly synaptic failure...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 68; no. 1; p. 33
Main Authors Wang, Xin, Zimmermann, Helena R, Ma, Tao
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2019
Subjects
signaling transduction
AMPK
protein synthesis
synaptic plasticity
Alzheimer’s disease
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Summary:Currently there is no cure or effective disease-modifying therapy for Alzheimer's disease (AD), the most common form of dementia that is becoming a global threat to public health. It is important to develop novel therapeutic strategies targeting AD pathophysiology particularly synaptic failure and cognitive impairments. Recent studies revealed several molecular signaling pathways potentially linked to brain pathology and synaptic failure in AD, including AMP-activated protein kinase (AMPK), a master kinase that plays a central role in the maintenance of cellular energy homeostasis. Particularly, hyperactive AMPK via phosphorylation has been linked to AD-associated synaptic plasticity impairments, indicating suppression of AMPK activity might be beneficial for cognitive deficiency in AD. In this review, we will discuss how targeting dysregulation of AMPK signaling could be a feasible therapeutic approach for AD.
ISSN:1875-8908
DOI:10.3233/jad-181043