Revisiting the paradigm of myostatin in vertebrates: Insights from fishes

Highlights • The sequence of MSTN protein is extremely well-conserved between fish and other vertebrates. • Fish species possess up to four mstn gene paralogs with a widespread expression. • Tools to specifically inactivate mstn genes still needed. • In fish mstn paralogs should have different funct...

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 194; pp. 45 - 54
Main Authors Gabillard, Jean-Charles, Biga, Peggy R, Rescan, Pierre-Yves, Seiliez, Iban
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2013
Elsevier
Subjects
Animals
atrophy
cell growth
cell proliferation
endocrinology
Endocrinology & Metabolism
fish
Fishes - growth & development
Fishes - metabolism
GDF8
genes
Life Sciences
mammals
messenger RNA
muscle development
Muscle growth
muscles
myostatin
Myostatin - genetics
Myostatin - metabolism
Salmonidae
Satellite cells
TALEN
transforming growth factor beta
Transgenesis
Vertebrates - growth & development
Vertebrates - metabolism
Zing finger nuclease
Zing finger nuclease
Muscle growth
Satellite cells
Transgenesis
TALEN
GDF8
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Summary:Highlights • The sequence of MSTN protein is extremely well-conserved between fish and other vertebrates. • Fish species possess up to four mstn gene paralogs with a widespread expression. • Tools to specifically inactivate mstn genes still needed. • In fish mstn paralogs should have different function aside from muscle growth regulation.
Bibliography:http://dx.doi.org/10.1016/j.ygcen.2013.08.012
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.08.012