The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

• Published in: Marine drugs Vol. 20; no. 1; p. 69
• Main Authors: Yu, Dawei, Feng, Jiayao, You, Huimin, Zhou, Shipeng, Bai, Yan, He, Jincan, Cao, Hua, Che, Qishi, Guo, Jiao, Su, Zhengquan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.01.2022; MDPI
• Subjects: Alzheimers disease; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics; Anticancer properties; antimicrobial; Antimicrobial agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; antitumor; Antitumour agents; Aquatic Organisms; Biological activity; Carbohydrates; Chitosan; Chitosan - chemistry; Chitosan - pharmacology; chitosan oligosaccharide; Degradation products; derivatives; Hydroxyl groups; Marine resources; Microstructure; Nitrogen; Oligosaccharides; Oligosaccharides - chemistry; Oligosaccharides - pharmacology; Review; Structure-Activity Relationship; Viscosity; antimicrobial; derivatives; antitumor; chitosan oligosaccharide
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md20010069

Chitosan obtained from abundant marine resources has been proven to have a variety of biological activities. However, due to its poor water solubility, chitosan application is limited, and the degradation products of chitosan oligosaccharides are better than chitosan regarding performance. Chitosan oligosaccharides have two kinds of active groups, amino and hydroxyl groups, which can form a variety of derivatives, and the properties of these derivatives can be further improved. In this review, the key structures of chitosan oligosaccharides and recent studies on chitosan oligosaccharide derivatives, including their synthesis methods, are described. Finally, the antimicrobial and antitumor applications of chitosan oligosaccharides and their derivatives are discussed.