Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore,...

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Published inNutrients Vol. 11; no. 1; p. 113
Main Authors Nam, Youn Hee, Rodriguez, Isabel, Jeong, Seo Yeon, Pham, Thu Nguyen Minh, Nuankaew, Wanlapa, Kim, Yun Hee, Castañeda, Rodrigo, Jeong, Seo Yule, Park, Min Seon, Lee, Kye Wan, Lee, Jung Suk, Kim, Do Hoon, Park, Yu Hwa, Kim, Seung Hyun, Moon, In Seok, Choung, Se-Young, Hong, Bin Na, Jeong, Kwang Won, Kang, Tong Ho
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.01.2019
MDPI
Subjects
Alcohol
Apoptosis
Auditory system
Avocado oil
Biosynthesis
Cochlea
Ethanol
Fatty acids
Functional foods & nutraceuticals
Gene expression
Hair
hair cell
Hair cells
Hearing
Hearing loss
HEI-OC1
In vivo methods and tests
Linolenic acid
mice
Mode of action
Mutation
Neomycin
Noise
Oils & fats
Otolaryngology
Oxidative stress
Phalloidin
Pharmaceutical sciences
Pharmacy
Protein biosynthesis
Protein synthesis
Rhodamine
sensorineural hearing loss
Zebrafish
United States > US
sensorineural hearing loss
avocado oil
zebrafish
HEI-OC1
mice
hair cell
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Summary:Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.
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These two authors contributed equally to this work.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11010113